Chandramouli C, et al. - Researchers used the Asian Sudden Cardiac Death in HF (ASIAN-HF) registry, to assess gender-based disparities in clinical and echocardiographic features, as well as in quality of life and 1-year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM). Overall 5,255 patients (mean age 59.6 ± 13.1, 78% men) with symptomatic HF with reduced ejection fraction (HFrEF) were examined. Participants were stratified by DM status. Findings revealed that the presence of DM was more likely to be seen in Asian women with HFrEF vs men (even with a lean body mass index), a greater burden of chronic kidney disease and more concentric left ventricular geometry vs men. Also, regardless of sex, worse quality of life was associated with DM. Among women with DM, a greater risk of adverse outcomes was observed vs men with DM. Sex-specific tactics to manage diabetes are needed in patients with HF.