Fridh EB, et al. - Researchers investigated how sex, comorbidities, and medication influence amputation and mortality risk associated with chronic limb threatening ischaemia (CLTI) via performing a population based observational cohort study including all individuals revascularised for CLTI in Sweden during a five year period (10,617 patients in total). In revascularised CLTI patients, renal insufficiency was the strongest independent risk factor for both amputation and amputation/death, followed by diabetes and heart failure. Compared to women, men with CLTI showed worse outcomes. Findings seem valuable for selecting the patient for revascularisation procedures. They noted improved limb outcome in association with statin and low dose acetylsalicylic acid. Thereby suggesting the significance of preventive medication to reduce general cardiovascular risk and increase limb salvage.