Mayberry S, Nechuta S, Krishnaswami S., et al. - This study was undertaken to investigate benzodiazepines, polysubstance overdose status with/without benzodiazepines, and mental health comorbidities with repeat overdose applying statewide data in Tennessee (TN). The study examined TN hospital discharge data on nonfatal overdoses for patients ages 18–64 for 21,066 patients with an initial inpatient visit and 36,244 patients with an initial outpatient visit between 2012 and 2016. Researchers tested each patient 1 year following the initial overdose to evaluate the likelihood of repeat overdose. A Cox proportional hazards model was applied to calculate hazard ratios (HRs) and 95% confidence intervals to ascertain the factors correlated with repeat nonfatal overdose. According to results, benzodiazepine/polysubstance status and mental health disorders were correlated with repeat overdose for inpatients; benzodiazepine/polysubstance status was correlated with repeat overdose for outpatients. Data support the requirement to include the polysubstance status and mental health in overdose prevention efforts. Factors found to be independently linked with repeat overdoses among inpatients were polysubstance status, benzodiazepine/polysubstance interaction, and presence of any mental health disorder, while for outpatients, benzodiazepine/polysubstance interaction was significant without adjusting for demographic factors.