Li A, Thompson AC, Asrani S, et al. - In this retrospective reliability analysis, researchers determined the prevalence of artifacts on segmented SDOCT images and evaluated their effect on the interpretation of glaucomatous progression in the retinal nerve fiber layer (RNFL) profile and macular thickness map. During a one-month period, retrospective review of glaucoma and glaucoma suspect eyes imaged with SDOCT. One hundred ninety eyes with 760 sets of OCT RNFL and macular scans were involved. Data reported that 50% (N = 96/190) of eyes had artifacts, either in the circumpapillary RNFL (N = 83/190; 43.68%) or the macula (N = 57/190; 30.0%). In multivariable analysis, severe glaucoma, hypertension, and age were significantly linked to the presence of artifacts on RNFL. According to findings, artifacts on both circumpapillary RNFL and macular scans on SDOCT images acquired at a glaucoma clinic are highly prevalent. Artifacts will result in false positive and false negative interpretation of progression while using only the auto-segmentation change maps. Therefore, to identify artifacts and true glaucoma progression, careful examination of the raw B-scan images of both the RNFL and macula is important.