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Impact of antiretroviral treatment on height evolution of HIV infected children

BMC Pediatrics Aug 21, 2019

Traisathit P, Urien S, Le Coeur S, et al. - Since antiretroviral treatment (ART) has been shown to have a beneficial impact on the weight evolution but its impact on height remains unclear, researchers characterized patterns of height evolution and identified predictors of catch-up growth in HIV-infected children on ART. They developed a nonlinear mixed effect model utilizing data from perinatally HIV-infected children who started ART from 1999 to 2013 in a prospective cohort study in Thailand to describe the height evolution from birth to adulthood. Over a median duration of 6.3 years on ART, a total of 477 children contributed 18,596 height measurements. Non-nucleoside reverse transcriptase inhibitor-based was the most frequent regimen at ART initiation. According to findings, the younger the children at the initiation of ART, the greater the effect on the velocity of height growth, supporting the recommendation of the World Health Organization to start ART as soon as possible. However, at the initiation of ART, the final adult height was not associated with the age.
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