Orayj K, et al. - Newly diagnosed Parkinson’s disease (PD) patients who used antidepressants were compared with those who did not, in terms of 1-year risk of ischemic heart disease (IHD), all cardiovascular events, and all-cause mortality in this study utilizing data from 2000 through 2016 held within the Welsh Secure Anonymized Information Linkage databank. Overall 3364 participants were included, with numbers divided equally between the antidepressant-user and non-user groups, on the basis of propensity score-matching process. No elevated risk of IHD or all cardiovascular events was observed in relation to antidepressant use in newly diagnosed PD patients with depression. A decrease in death rate might be achieved in PD patients during the first year after initiation of antidepressants.