Enhos A, et al. - The present study was conducted to explore the effect of antecedent aspirin use on infarct size, bleeding, and composite endpoint in patients with de novo acute myocardial infarction. Researchers enrolled a total of 562 consecutive patients with de novo acute myocardial infarction in this prospective cohort study. Individuals were allocated into two groups based on presence (n=212) and absence (n=350) of prior aspirin use. The results of this research demonstrate that individuals with de novo acute myocardial infarction using aspirin for primary prevention have an unexpectedly smaller infarct size and similar bleeding rates.