Hsu CY, et al. - Via analysis of two prospective cohorts (the Assessment, Serial Evaluation, and Subsequent Sequelae of acute kidney injury {AKI} study and the subset of the Chronic Renal Insufficiency Cohort study) of 2,048 eligible participants, the researchers intended to determine the potential effects of AKI on proteinuria (the strongest risk factor for future loss of renal function). Three hundred and twenty-four individuals, during 9,271 person-years of follow-up, encountered at least one episode of hospitalized AKI. An independent association of an episode of hospitalized AKI with a 9% elevation in the urine protein-to-creatinine ratio was observed. Hence, it was ascertained via the study based on two cohorts that subsequent deterioration of proteinuria was independently correlated to hospitalization for an AKI episode.