Ma Z, Cheng X, Yue T, et al. - Researchers aimed at ascertaining how immune infiltration affects the development of prostate adenocarcinoma (PRAD) and its clinical presentation. PRAD patients were categorized into high and low-level clusters based on immune infiltration phenotypes. Worse survival was recorded for patients in the high-level clusters compared with their low-level counterparts. In gene set enrichment analysis, both anti- and pro-tumor terms were noted to be enriched in high-level cluster. In addition, a positive correlation was observed between anti- and pro-tumor immune cells in PRAD microenvironment. Somatic mutation analysis indicated a higher somatic mutation burden of KMT2D, HSPA8, CHD7, and MAP1A among patients in high-level cluster. Furthermore, an immune prognostic model (IPM) with robust predictive ability for unfavorable prognosis was developed. Besides, a nomogram incorporating Gleason score, pathological T stage, and IPM, was developed for predicting prognosis of PRAD patients, which displayed robust predictive ability and might contribute to clinical practice. Overall findings suggest strong correlation of the immune infiltration phenotypes with the poor prognosis of PRAD patients, and emphasized the potential of the IPM to identify unfavorable tumor features.