Fu Y, Tang Y, Zheng Y, et al. - In this study, the effect of imaging patterns on the outcomes of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment was investigated. Researchers included a cohort of treatment-naive non-small cell lung cancer patients harboring EGFR mutation with intrapulmonary metastases who were prescribed with TKI. They reviewed and examined demographic feature, clinical outcome, and CT imaging of each patient. Among a total of 174 patients there were five intrapulmonary patterns of imaging recognized: solid nodular, ground-glass nodular, miliary, multiple uniform nodular, and not otherwise specified. Miliary and multiple uniform nodular patterns had similar poor prognosis, so they were combined as diffuse group; compared to the rest these patients had worse PFS. The OS of the diffuse and the non-diffuse group were 25.6 months and 35.0 months, respectively. In the non-diffuse group,  brain and leptomeningeal metastases was less common with marginal statistical significance. Following TKI treatment, individuals with diffuse intrapulmonary metastases had inferior outcomes. More aggressive treatments might be needed for these individuals.