Mathew D, Rubin G, Mahomed N, et al. - Via performing a quantitative analysis among three tertiary hospitals in South Africa, researchers sought to describe the disease burden of breast tuberculosis (TB), with correlation to their clinical, demographic, and imaging features. They assessed 2,516 patients who underwent laboratory investigations for breast disease at the mammography departments of these three tertiary centers and identified breast TB prevalence of 2.5% (n = 62; median age at presentation: 38.5 years). Among 45/62 patients with known HIV status, 36 were HIV infected (80%). The ultrasound and/or mammogram findings led to categorization of the patients into five categories: TB breast abscess (40.3%), inflammatory/disseminated (24.2%), isolated TB lymphadenitis (22.6%), nodular (11.3%), and sclerosing form (1.6%). Per histology, 57 cases (92%) had necrotising granulomatous inflammation. Findings emphasize the significance of knowledge of the varied clinical and radiological features to maintain a high degree of suspicion to limit incorrect diagnoses, inappropriate management, and complications. As ultrasound-guided core biopsy yields a better tissue sample and more often a positive diagnosis, it is advocated as the first-line intervention in diagnosing or excluding this disease rather than fine-needle aspiration.