Lund KP, et al. - Researchers examined the impact of systemic inflammation at the time of kidney transplantation on graft survival, major adverse cardiovascular events (MACE), and increased mortality. Further, the investigated modulation in these processes in correlation with naturally occurring cytokine-specific autoantibodies (c-aAbs), which have been shown to regulate cytokine activity in vitro. They performed a retrospective cohort study of 619 kidney transplanted patients with a median follow-up of 4.9 years measuring serum levels of cytokines, high-sensitivity C-reactive protein (hsCRP) and c-aAbs specific for interleukin (IL)-1α, tumor necrosis factor (TNF)-α, IL-6, and IL-10 at the time of transplantation. Findings support the pathological driving role of pro-inflammatory activity before transplantation for MACE and all-cause mortality after transplantation.