Lundström SL, et al. – The scientists intended to figure out whether immunoglobulin G (IgG) glycosylation in untreated early rheumatoid arthritis (RA) could predict therapeutic response to methotrexate (MTX). Their investigations displayed that the FA2/[FA2G1 + FA2G2] of IgG1 was a biomarker candidate that was significantly associated with nonresponding patients and had potential value for the prediction of MTX clinical response.