Sevillano AM, et al. - Researchers analyzed a cohort of 151 patients ≥65 years old with biopsy-proven IgA nephropathy, to determine the incidence, patterns of presentation, clinical and histologic features, treatments received, and results in this retrospective multicentric investigation. A composite end point of kidney replacement therapy or death prior to kidney replacement therapy was the primary outcome. Overall 84 patients presented with asymptomatic urinary abnormalities, 61 patients with AKI. For the entire cohort, 74%, 48%, and 26% were the estimated survival rates without the composite end point at 1, 2, and 5 years, respectively. The risk factors that showed a significant relation to the outcome were age, serum creatinine at presentation, and the degree of interstitial fibrosis in kidney biopsy. A lower risk was reported in relation to treatment with renin-angiotensin-aldosterone blockers. Overall, a progressive rise in IgA nephropathy diagnosis among older adults has been reported in Spain in recent years. This trend could, in part, be attributable to anticoagulant therapy. Poor prognosis was reported.