Flory JH, et al. - Using electronic health record data from a network of urban academic practices, a retrospective cohort study was conducted to evaluate reasons for metformin non-persistence, and whether initial metformin dosing or use of extended release (ER) formulations affect persistence to metformin therapy. The routine prescribing of low starting doses of metformin as a tool to improve persistence was supported. The data presented in this work showed a strategy of starting metformin at minimal dose improved persistence. It was noted that only half of the providers routinely use that dosing strategy.