Brown DMY, Kwan MY, Arbour-Nicitopoulos KP, et al. - Researchers sought to determine whether unique adolescent movement behaviour profiles exist, to analyze profile membership predictors, and to determine whether profile membership was correlated with cross-sectional and longitudinal differences in depressive symptoms. This investigation included a secondary analysis of the public-use data from Wave 1 and Wave 2 of the National Study of Adolescent Health. Adolescents (N = 6,436; 48% male) in grades 7 to 12 (Mage = 16.03 ± 1.75) completed measures to assess moderate-to-vigorous physical activity (MVPA), recreational screen time (ST), sleep – collectively known as movement behaviors – and depressive symptoms. After adjusting for covariates, the results showed depressive symptoms were lowest among the high MVPA/low ST profile, and this pattern was clear one year later. Involving high levels of either MVPA or ST alone did not have additive benefits for depressive symptoms relative to those with low levels of both MVPA and ST. Such results indicate that intervention efforts should take an integrative approach to enhance mental health outcomes among teenagers by considering each of the movement behaviors at the same time.