Asadollahi S, et al. - In this investigation involving 25 individuals (10 male and 15 female; mean age was 55 years), researchers evaluated the iatrogenic risk to the superficial femoral artery (SFA) during Less Invasive Stabilisation System (LISS) plate fixation of distal femoral fractures by examining the range of distances and angles between LISS plate screws and the drilling line to the SFA. All individuals who had LISS plate fixation of distal femoral fractures between 2008 and 2018 in the level-1 trauma centre were identified. A supracondylar femur fracture followed by an intercondylar fracture was the most common fracture type. Data reported that the mean distance between the screw tip and the SFA was 21 mm (range, 8-65 mm). A negative link was found between the LISS plate hole number and the trajectory of drilling. Using a linear regression model, when using the 6^th to 10^th holes in the LISS plate, the SFA was more likely to be in the drilling line. To lessen the risk of iatrogenic injury to the SFA, particularly in the high-risk plate zone where the artery may be close to the drilling line, extra care is needed when drilling into the LISS plate holes from the lateral to the medial direction.