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Identification of asthma-COPD overlap, asthma, and chronic obstructive pulmonary disease phenotypes in patients with airway obstruction: Influence on treatment approach

Respiration Nov 15, 2019

Romem A, Rokach A, Bohadana A, et al. - Among individuals referred for pulmonary function testing (PFT), with airway obstruction in spirometry (forced expiratory volume in 1 s/forced vital capacity < 0.7), researchers focused on the prevalence of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO), asthma, and COPD phenotypes, as well as on the therapeutic approach of each group in this cross-sectional analysis. Participants were cases referred for PFT at the Rokach Institute, in Jerusalem. Among the overall study sample, > 1/3 of patients had ACO. A tendency of ACO patients to be predominantly female, be older than asthmatics, be smokers, to have worse health-related quality of life in the activity domain and have more exacerbations, was noted. The treatment received by ACO patients was similar to that received by COPD patients, despite a clearly identifiable phenotype, this indicates poor ACO identification. So that better recognition and appropriate treatment in individual patients be guided, it is required to increase the awareness of ACO among clinicians.
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