Zurawski J, et al. - Via analyzing 2,302 patients, aged 52.8 ± 10.8 years, from the Comprehensive Longitudinal Investigation of Multiple Sclerosis at Brigham and Women’s Hospital (CLIMB) study, researchers described the clinical course and neurocognitive impairment of individuals with multiple sclerosis (MS) meeting an Expanded Disability Status Scale (EDSS)‐defined cognitive phenotype. The authors discovered that the mean cohort annualized relapse rate was 0.38 and EDSS score at last clinical assessment was 3.2 ± 1.3. An association was found between cognitive phenotype designation and low rate of employment at last clinical assessment. Predominant cognitive MS phenotype is uncommon as an EDSS‐based definition distinguishes patients with multidomain cognitive impairment and may serve as a practical screen for recognizing patients who may require close monitoring of neurocognitive status.