Fukuda S, Kita S, Miyashita K, et al. - Researchers conducted this cross-sectional observational study to validate the existence of T-cad forms in human serum and examine the correlation with clinical parameters of type 2 diabetes patients. Serum T-cad concentrations were assessed for 183 Japanese type 2 diabetes patients. In human serum, there were three types of soluble T-cad, a 130-kDa form with a prodomain, a 100-kDa mature form, and a 30-kDa prodomain. Three novel forms of soluble T-cad have been identified and need further study into their significance as disease markers and/or biomarkers of adiponectin function and the possible bioactivity of the respective molecules.