Kaspar CDW, et al. - By analyzing the first 78 pediatric sickle cell disease (SCD) patients from a cohort study in this cross-sectional analysis, researchers focused on the impact of hyperuricemia on renal function in SCD. They characterized the mechanism of occurrence of hyperuricemia (defined, serum uric acid (UA) ≥ 5.5 mg/dL) due to either UA overproduction or inefficient renal excretion by the Simkin index and fractional clearance of urate equations. In this young population (mean age 11.6 ± 3.77 years), the prevalence of hyperuricemia was estimated to be 34.2%. Overall, a likely link was suggested between hyperuricemia and early estimated glomerular filtration rate decline in sickle cell nephropathy. .