Agondi RC, Dias GMFS, de Assis JP, et al. - In this study with 73 adult asthmatic patients with aspirin-exacerbated respiratory disease (AERD) observed at a tertiary hospital, researchers intended to phenotype patients with AERD based on the presence of atopy, urticaria and level of peripheral eosinophils. Overall 68.5% of patients had severe asthma and 67.1% had respiratory exacerbation with dipyrone. Findings revealed a high prevalence of severe asthma in AERD patients. Likewise, urticaria was shown to be quite prevalent and its presence was identified to be related to dipyrone induced hypersensitivity reaction. Half of the patients had atopy, with no link with asthma severity. More severe asthma was observed in patients who exhibited higher levels of peripheral eosinophils. Experts suggested dypirone hypersensitivity as a possible marker for concomitant respiratory and cutaneous hypersensitivity reactions.