Ospina-Romero M, et al. - In the MEGA case-control study (1999–2004) from the Netherlands (1,689 cases and 1,726 controls), researchers investigate if hyperhomocysteinemia is associated with venous thrombosis (VT), taking into account measured and unmeasured confounders. This study does not demonstrate the association of hyperhomocysteinemia with an increased risk of venous thrombosis after extensive adjustments for confounding.