Wu CL, et al. - Researchers examined the long-term association of hydroxychloroquine use with the risk of developing CKD in this observational cohort study in patients with newly diagnosed rheumatoid arthritis who were enrolled prospectively in Taiwan’s National Health Insurance Research Database between January 1, 2000 and December 31, 2013. The link was analyzed using multivariable Cox proportional hazard regression. A lower risk of incident CKD was found in hydroxychloroquine users, compared with hydroxychloroquine nonusers, even after multivariable adjustment. The lower risk of subsequent CKD development was found to be dose-dependent and was consistent across subgroup analyses. Overall, in these subjects, use of hydroxychloroquine was related to a significantly lower risk of incident CKD, relative to nonusers.