Wu SF, et al. – In this research work, the scientists examined the effects of hydroxychloroquine (HCQ) on CD154 in systemic lupus erythematosus (SLE). They described that HCQ inhibited NFAT signaling in activated T cells and blocked the expression of membranous CD154, but not STAT5 signaling. These findings provided a mechanistic insight into SLE in HCQ treatment.