Ceccato F, Tizianel I, Vedolin CK, et al. - Researchers evaluated the diagnostic accuracy of the hCRH^test [human corticotropin-releasing hormone (CRH) test] which is employed to distinguish Cushing disease (CD) from ectopic adrenocorticotropin (ACTH) secretion (EAS), to evaluate autonomous cortisol secretion by the adrenal glands as well as to characterize pseudo-Cushing syndrome (CS) or adrenal insufficiency. In this cross-sectional study, ACTH and cortisol levels were recorded; the peak values (peak^ACTH and peak^cortisol) were obtained, and the percentage rises (∆%^ACTH and ∆%^cortisol) following an intravenous bolus of 100 μg hCRH were computed. This analysis involved 200 patients. In CD, higher peak^ACTH and peak^cortisol were detected, and ∆%^ACTH and ∆%^cortisol enabled the differentiation of CD from EAS with a sensitivity and specificity more than 80%. Based on the findings, experts concluded hCRH^test test to be the mainstay of the differential diagnosis of ACTH-dependent CS. They also suggested its worth for pointing to a diagnosis of CD in the event of bilateral adrenal masses, as well as in patients exhibiting low basal^ACTH.