Abouhussein MA, et al. - In this retrospective case series, researchers assessed the effectiveness of the human amniotic membrane in promoting closure of macular holes coexisting with rhegmatogenous retinal detachment. The sample consisted of 14 eyes (14 patients) with the macula off retinal detachment. Data reported that the mean preoperative BCVA (logMAR value) was 1.87 ± 0.31. The mean LogMAR best-corrected visual acuity was 0.67 ± 0.17 at the 6-month follow-up visit. All patients displayed complete retinal reattachment with macular hole closure at the 6-month follow-up. According to findings, use of the human amniotic membrane for macular holes coexisting with rhegmatogenous retinal detachment is a valid option in surgery.