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Hospitalizations among adults with chronic kidney disease in the United States: A cohort study

PLoS Medicine Dec 16, 2020

Schrauben SJ, Chen HY, Lin E, et al. - Given that hospitalization more often occurs in adults with chronic kidney disease (CKD) vs those without CKD, however, there is a lack of proper understanding of the magnitude of this excess morbidity and the factors related to hospitalizations, therefore, researchers estimated primary reasons of hospitalizations, hospitalization rates, as well as baseline participant factors related to all-cause, cardiovascular, and non-cardiovascular hospitalizations during a median observation span of 9.6 years among 3,939 participants enrolled in the Chronic Renal Insufficiency Cohort Study. Findings revealed a higher hospitalization rate in adults with CKD vs the general population that was hospitalized, and increased rates of hospitalization were noted in relation to even moderate declines in kidney function. Reasons for hospitalization were mainly associated with cardiovascular disease, however, the contribution of other causes was also evident, especially of genitourinary, digestive, and endocrine, nutritional, and metabolic illnesses. High levels of proteinuria had the largest link with hospitalizations across a broad range of kidney function levels.

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