Fernandes T, et al. - Researchers sought to assess the laboratory and endometrial safety of topical testosterone vs topical estrogen for the treatment of vaginal atrophy in postmenopausal women. In this was a randomized, placebo-controlled trial of 60 postmenopausal women aged 40 to 70 years performed at the Menopause Clinic of CAISM UNICAMP, they randomized women into three vaginal treatment groups: estrogen, testosterone, or placebo. Outcomes suggested 12 weeks of treatment with topical testosterone or estrogen to have laboratory and endometrial safety when compared with placebo in postmenopausal women with symptoms of vaginal atrophy.