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Hormonal factors in association with lung cancer among Asian women: A pooled analysis from the International Lung Cancer Consortium

International Journal of Cancer Nov 23, 2020

Jin K, Hung RJ, Thomas S, et al. - Researchers performed this International Lung Cancer Consortium pooled analysis, with 2,456 lung cancer cases and 5,342 controls, to examine estrogen‐related hormonal factors and lung cancer among Asian women. Late onset of menarche, with an adjusted odds ratio (OR) of 1.24 for 17 years or older vs 14 years or younger, correlated with increased odds of lung cancer. Lung cancer also correlated with both a late onset of menopause at 55 years old or older (OR=1.24) and non‐natural menopause (OR=1.39). A lower chance of lung cancer was demonstrated by more live births vs 0‐2 live births (OR=0.71), though having a first child later appeared related to an elevated susceptibility (OR of 21‐25 years old: 1.23; 26 or older: 1.27). A seemingly protective impact of oral contraceptives use (OR=0.69), was reported. Though stronger for adenocarcinoma vs squamous cell carcinoma, these associations were not obviously altered by smoking status, likely due to lower prevalence of smoking. Findings of this first and largest pooling study of lung cancer in Asian women indicated that hormone‐related pathways may have roles in the etiology of this disease.

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