Ooi KGJ, et al. - Authors assessed 13 full thickness eyelid specimens to estimate the 3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) expression in human meibomian gland epithelial cells (HMGECs) and eyelid tissue. They used rabbit anti-human HMGCR antibody on serial sections using the Ventana automated staining system to perform immunohistochemistry. They observed meibomian glands in all the specimens, glands of Zeis in 2, pilosebaceous glands in 3, accessory lacrimal glands in 2 and glands of Moll in 2. They noticed HMGCR expression in all eyelid sebaceous-type glands and in HMGECs, indicating its role in cholesterol production in the genesis of tear film lipids. They also explained the use of topical statins, inhibitors of HMGCR, as novel tear film lipid stabilizers in ailments like blepharitis, where meibum production was anomalous.