Yusuf H, Fields E, Arrington-Sanders R, et al. - Via this review, researchers sought to report on the current status of preexposure prophylaxis (PrEP) uptake for HIV prevention among at-risk adolescents aged 13 to 19 years and assessed recommendations for enhancing PrEP access, uptake, and future needed directions, including specific recommendations for health care professionals. In 2018, 37,377 new HIV diagnoses were made including 7,734 diagnoses (21%) in adolescents and young adults aged 12 to 24 years; of these 7,734 diagnoses, 1,707 diagnoses (22%) occurred in adolescents aged 13 to 19 years. Young African American men who have sex with men were identified bearing the greatest burden of HIV , accounting for two-thirds of all HIV infections in adolescents and young adults. Adolescents with the greatest risk for HIV were identified to exhibit lowest preexposure prophylaxis awareness and engagement. For optimization of uptake, they emphasize improving clinicians’ knowledge concerning HIV risk and prevention strategies, increasing sexual history taking and risk assessment through training and retraining, and enhancing PrEP knowledge and acceptance of prescribing among clinicians. In adolescents at greatest risk for HIV, mitigation of HIV transmission may occur with leveraging the ubiquity of social media, encouraging family support, and performing research aimed at finding lifestyle-congruent formulations.