Yusuf H, Fields E, Arrington-Sanders R, et al. - Researchers here conducted a review investigating the current status of preexposure prophylaxis (PrEP) uptake among at-risk adolescents aged 13 to 19 years. Further, they sought to provide recommendations for enhancing PrEP access, uptake, and future needed directions, including specific recommendations for health care professionals. In 2018, 37,377 new HIV diagnoses were made. Among these, 7,734 diagnoses (21%) were made in adolescents and young adults aged 12 to 24 years; of these, 1,707 diagnoses (22%) occurred in adolescents aged 13 to 19 years. Young African American men who have sex with men were identified bearing the greatest burden of HIV, accounting for two-thirds of all HIV infections in adolescents and young adults. Researchers suggest PrEP use in adolescents at risk for HIV as an important component of HIV prevention. Observations emphasize improvement in clinicians’ knowledge about HIV risk and prevention strategies, increase in sexual history taking and risk assessment through training and retraining, and improvement in PrEP knowledge and acceptance of prescribing among clinicians for optimizing uptake. HIV transmission could be reduced in adolescents at greatest risk for HIV via leveraging the ubiquity of social media, encouraging family support, and performing research aimed at finding lifestyle-congruent formulations.