Rocha Filho PAS, et al. - This cross-sectional study aimed to investigate the association between HIV and headache. A high frequency of headaches was observed in HIV-positive patients, which had a great effect on patients' lives. Migraine was the most often found pattern. No correlation was found between CD4 counts and the severity of headaches.

• The authors enrolled patients with HIV and CD4+ T lymphocyte counts >500.
• They used semi-structured interview, the Headache Impact Test (HIT-6), and the Hospital Anxiety and Depression Scale.

• 63% were men among the 119 cases included.
• In this study, the mean age was 35.5 ± 10.4 years.
• 103 (87%) had headaches, 53 (45%) had migraines, 50 (42%) had tension-type headaches, and 53 (45%) had substantial and severe impact of headaches among the patients.
• In this study, 11 patients had headaches that started after they had been diagnosed with HIV.
• These patients had more migraines (72% vs 43%; P < 0.05), greater intensity (8 ± 2 vs 6 ± 2; P < 0.01), and impact (HIT-6: 60 ± 11 vs 51 ± 12; P = 0.02) of headaches compared to others HIV patients.
• The authors found no associations between CD4 counts and the intensity, frequency, or impact of headaches.