Dijkstra M, et al. - Associations between HIV-1 status and decreased sexual functioning were assessed among MSM using cross-sectional data from 399 HIV-1-infected MSM mostly on combination antiretroviral therapy (cART) and 366 HIV-1-uninfected MSM aged at least 45 years participating in the AGE_hIV Cohort Study. HIV-1 status was identified to have an independent association with decreased erectile function among MSM aged at least 45 years. Independent risk factor for a decreased erectile function may include exposure to lopinavir/ritonavir among MSM with HIV-1.