Brescia G, et al. - Via retrospectively involving 32 consecutive adult patients with nasal polyposis treated with primary surgery who subsequently had revision surgery, researchers studied the histological changes in recurrent chronic rhinosinusitis with nasal polyps (CRSwNP) in terms of eosinophilic infiltrate, subepithelial edema, goblet cell hyperplasia, and basement membrane thickness. A significant positive correlation emerged between all histopathological parameters and between tissue eosinophil and blood eosinophil counts at primary surgery. There was also a positive correlation between subepithelial edema scores and blood basophil levels. The preliminary findings support the hypothesis that tissue remodelling is a dynamic process involving significant differences in tissue eosinophil counts between primary and recurrent CRSwNP due to surgical and medical treatments for CRSwNP. How tissue remodelling evolves after treatment with CRSwNP warrants further investigation, not only in larger patient series but also after stratifying patients by the time that has elapsed since treatment.