Delbet JD, Geslain G, Auger M, et al. - By performing this study with a pediatric population diagnosed with IgA vasculitis with nephritis (IgAVN), researchers focused on the prognosis of children with IgAVN in relation to histological parameters. Mesangial proliferation, endocapillary proliferation (EP), crescents, active, or chronic tubular and interstitial lesions (TIa lesions/TIc lesions), and segmental glomerulosclerosis were the histological parameters that were examined among the participants recruited from three pediatric nephrology centers. IgAVN remission was defined as a proteinuria < 200 mg/l in the absence of renal failure and was assessed as the primary endpoint. At the end of a 3-year follow-up, a persistent renal disease was present in 30% of the overall children with IgAVN included in the study. A bad prognosis related to chronic histological lesions, but not associated with EP or crescents, was reported and the assessment of chronic histological lesions in IgAVN histological classification is mandatory.