Ryan E, Eves D, Menon PJ, et al. - Since histological chorioamnionitis (HCA) was correlated with preterm birth and adverse neonatal outcomes, researchers assessed the rise in C-reactive protein (CRP) in preterm infants as a predictor of HCA severity and outcomes. The sample consisted of consecutive preterm infants, born January 2009 to January 2014 in the National Maternity Hospital, Dublin, under 32 weeks' gestation or < 1.5 kg birth weight. Five hundred eighteen preterm infants were involved with a mean gestational age 28.5 ± 2.8 weeks, birthweight 1.1 ± 0.3 kg and 53.5% were males. Data reported that histological chorioamnionitis was found in 25.4%. The authors discovered that histological chorioamnionitis was 93.7% for CRP > 5 mg/L, 65.2% for CRP 1-5 mg/L, and 19.4% for CRP < 1 mg/L, respectively. They observed that higher early CRP was HCA's surrogate predictor and correlated with HCA's severity. A CRP > 10 mg/L was linked to a foetal inflammatory response and increased early-onset sepsis. Histological chorioamnionitis was related to more resuscitation and respiratory distress syndrome. Findings suggested an association of higher CRP and HCA with adverse early outcomes.