Gabrielli L, et al. - In view of the findings from the Congenital Human Cytomegalovirus Infection Prevention (CHIP) study that the efficacy of hyperimmune globulin (HIG) was not different from that of placebo regarding transmission of cytomegalovirus (CMV) from mothers to newborns, researchers analyzed histologically HIG effects on placentas collected for the CHIP study. They noted that HIGs were not able to reduce placental viral load and histological damage, which was significantly associated only with infection.