El Sharouni MA, Aivazian K, Witkamp AJ, et al. - By examining data from 2 large cohorts of adult patients (one in the Netherlands and the other in Australia), researchers investigated if histologically corroborated regression was related to better or worse survival in patients suffering from primary cutaneous melanoma. The participants had histologically confirmed, stage 1 and 2 primary, invasive cutaneous melanoma with known regression status and were treated between 2000 and 2014. This study included 17,271 Dutch patients and 4,980 Australian patients. Patients with disease regression had better survival outcomes in both cohorts. Overall, regression was concluded as a favorable prognostic factor for patients suffering from stage 1 and 2 melanomas, particularly in those with thin and intermediate thickness tumors and those with superficial spreading melanoma subtype, in 2 large patient cohorts from 2 different continents.