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Higher body mass index in adolescence predicts cardiomyopathy risk in midlife: Long-term follow-up among Swedish men

Circulation Jul 17, 2019

Robertson J, et al. - In this nationwide register-based prospective cohort study, researchers analyzed adolescent men (n=1,668,893, mean age, 18.3 years; SD, 0.7 years) who registered for compulsory military service from 1969 to 2005 to determine if there is a connection between obesity in adolescence and being diagnosed with cardiomyopathy in adulthood. They found 4,477 cases of cardiomyopathy during a median follow-up of 27 years, these included 2,631 (59%) dilated, 673 (15%) hypertrophic, and 480 (11%) alcohol/drug-induced cases. Findings revealed a possible contribution of even minimally elevated body weight in late adolescence to a diagnosis of cardiomyopathy in adulthood. These findings not only further reinforced the already marked significance of weight control in youth but also offered greater evidence for obesity being a potentially significant reason for adverse cardiac remodeling that is independent of clinically evident ischemic heart disease.

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