Letendre S, et al. - Via performing this cross-sectional analysis, researchers investigated if cytomegalovirus (CMV) is associated with neurocognitive performance in adults infected with human immunodeficiency virus (HIV). They measured anti-CMV immunoglobulin G (IgG) concentrations in blood and CMV DNA copies in blood and cerebrospinal fluid (CSF) in stored specimens of 80 HIV-infected adults who were previously assessed with a comprehensive neurocognitive test battery. They noted higher anti-CMV IgG levels in association with older age, lower nadir CD4+ T-cell count, AIDS, and higher soluble CD163. Higher anti-CMV IgG levels trended toward an association with the overall worse neurocognitive performance. This suggests that CMV is correlated with neurocognitive performance among HIV-infected adults taking suppressive ART.