Janus SE, et al. - In a prospective cohort, the Chronic Renal Insufficiency Cohort (CRIC), including 3,939 people with mild to moderate chronic kidney disease (CKD) using age related criteria for GFR, researchers examined the link between high sensitivity troponin (HsTP) and risk of peripheral arterial disease (PAD) in CKD. This study included 2,909 participants free of PAD and CAD at enrollment. The participants were observed for a mean duration of 7.4 years, during which, the development of PAD was reported in 79 (2.7%) patients. A higher risk of PAD was observed in patients in the third quartile and fourth quartile of HsTP vs lowest quartile of HsTP, after adjusting for clinical risk factors of PAD. At 3 years, 6 years and 9 years, HsTP had good discrimination of PAD. Improved model discrimination of PAD was obtained by adding HsTP to Framingham risk score. Overall, findings revealed the link of HsTP levels with the risk of incident PAD in patients with mild-moderate CKD. In these patients, the risk of incident PAD was predicted by HsTP levels. Even after adjustment for conventional PAD risk factors and chronic kidney disease, this link continued to be significant.