High-sensitive cardiac troponin T and systemic right ventricular area predict outcomes in adults with congenitally corrected transposition
Canadian Journal of Cardiology Jul 18, 2018
Kowalik E, et al. - In adults with congenitally corrected transposition of the great arteries (ccTGA), researchers wanted to find screening tools that enable morbidity and mortality risk stratification. At baseline, electrocardiography, laboratory testing, echocardiography, and cardiopulmonary exercise testing were carried out, followed by a Cox proportional hazards regression analysis to establish determinants of composite clinical endpoints, including death, heart transplantation, systemic ventricular device assist implantation, worsening of heart failure, vascular events, tricuspid valve regurgitation requiring intervention, and clinically relevant arrhythmias. In this patient population, the best predictors of adverse clinical events were a combination of detectable high-sensitivity troponin T and an increased systemic right ventricular end-diastolic area.
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