Stentz FB, Mikhael A, Kineish O, et al. - Researchers assessed the response to High Protein (HP) vs High Carbohydrate (HC) Diets in terms of incretin hormones GLP-1 and GIP, the hunger hormone ghrelin and BNP, which is related to cardiac function. They sought to determine whether HP diets result in more pronounced release of glucose lowering hormones, suppress hunger as well as improve cardiac function. This analysis involved 24 obese women and men with prediabetes. The participants were randomly assigned to either a HP (n = 12) or HC (n = 12) diet for 6 months with all food provided. Findings revealed that HP diet, compared with HC diet, resulted in a rise in GLP-1 and GIP which may be responsible partially for improved insulin sensitivity and β cell function. HP ghrelin results show the greater effectiveness of the HP diet in attenuating hunger, relative to the HC diet. In addition, significant improvements in BNP and other CVRF, metabolic parameters and oxidative stress were noted, in comparison with the HC diet.