Einarsdottir MJ, et al. - In this retrospective cohort study, researchers estimated the prevalence of glucocorticoid (GC) use in terms of doses correlated with the risk of tertiary adrenal insufficiency in children and adults, and treatment indications. From the Swedish Prescribed Drug Register, information on dispensed prescriptions was obtained. They included patients with prescriptions of prednisolone (or equivalent dose of other GCs) ≥ 5 mg daily for ≥ 21 days between 2007 and 2014. Of 1,585,335 inhabitants in Västra Götaland County, 223 211 were incorporated in the research. During the 8-year study period, period prevalence of oral GC use was 14.1%. Men aged 80-89 years had the highest prevalence and men aged 10-19 years were the lowest. In children 0-9 years of age, the period prevalence was 10.6%. The most common indications for treatment followed by allergy and malignant neoplasms were COPD and asthma. In children and adolescents, allergy was the most frequent indication. Every seventh inhabitant in western Sweden received a GC prescription at doses related to risk of developing tertiary adrenal insufficiency between 2007 and 2014. Such results demonstrate the importance of education in paediatric and adult patients about the potential development of tertiary adrenal insufficiency.