Jensen ET, Aceves SS, Bonis PA, et al. - Utilizing data collected from a patient contact registry, researchers described and contrasted patient-reported gastrointestinal and extragastrointestinal symptoms and comorbidities in non-eosinophilic esophagitis (EoE) eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic gastritis, gastroenteritis and colitis, relative to EoE. They performed a cross-sectional study of contact registry data collected from 2015 to 2018. Of the 715 reporting an EGID diagnosis, a higher proportion of those with a non-EoE EGID documented more frequent specific and nonspecific gastrointestinal symptoms such as nausea, abdominal pain, diarrhea, constipation, and bloating. Candidates with a non-EoE EGID were more likely to experience higher frequency of fatigue, isolation, and deep muscle or joint pain. There are major variations in the symptoms and comorbidities between people with EoE vs non-EoE EGIDs. In order to elucidate the factors that may lead to the high disease burden of these poorly understood conditions, further research is required.