Taylor RS, Bentley A, Campbell B, et al. - In view of the inscribed evidence supporting effectiveness of spinal cord stimulation (SCS) for reducing chronic back and leg pain (CBLP) and SENZA randomized controlled trial demonstrating clinically superiority of high-frequency (10 kHz) stimulation (10 kHz-SCS) relative to traditional low-frequency SCS (LF-SCS), researchers here performed cost-consequence and cost-effectiveness analysis of 10 kHz-SCS vs LF-SCS. Employing a probabilistic decision tree and Markov decision analytic model, they synthesized data on CBLP outcomes and costs over a 15-year time horizon from a UK National Health Service perspective using data from the SENZA randomized controlled trial and other publications. Findings revealed 10 kHz-SCS as a cost-saving and cost-effective option compared with LF-SCS. Mean cost-savings of £7,170 (95% confidence interval: £6,767-£7,573) and £3,552 (95% confidence interval: £3,313-£3,792) were reported per patient compared with nonrechargeable and rechargeable LF-SCS devices, respectively. In addition, 10 kHz-SCS has clinical benefits not captured in this analysis, including shorter, and more predictable procedure times.