Sharluyan A, Osona B, Frontera G, et al. - In children undergoing fiberoptic bronchoscopy (FB), optimized oxygenation as well as a significant reduction in desaturations during the procedure were achieved with the use of high-flow nasal cannula therapy (HFNC) and it can be considered for oxygen delivery, especially when bronchoalveolar lavage (BAL) is performed.

• Hypoxemia is the most frequent complication of FB in children.

• This prospective randomized controlled, nonblinded, single-center clinical trial was conducted with patients aged 1 month–16 years undergoing elective FB.

• They were randomized to receive oxygen through conventional nasal prongs (NC) (n = 53) or HFNC (n = 51).

• Hypoxemia was less likely to occur in HFNC patients vs NC patients, with an absolute risk reduction of 0.27.

• With HFNC, moderate hypoxemia was noted significantly less often relative to NC.

• HFNC was associated with fewer desaturations in patients receiving BAL.