Liu J, et al. - Researchers identified chemokine receptors (highly expressed in various cancers and play crucial roles in tumor progression) which play a critical role in the progression of melanoma and unravel the molecular mechanisms underlying it. The C-C chemokine receptor 5 (CCR5) in melanoma cells was more abundant than normal cells and was positively related to tumor malignancy in clinical patients. CCR5 mechanistically regulated the expression of the Transforming Growth Factor β1 (TGFβ1), which in turn induced epithelial-mesenchymal transition (EMT) and PI3K/AKT/GSK3β signaling migration. The outcomes establish a critical role of CCR5 in cancer progression expressed by melanoma cells and reveal the novel mechanisms that control this process, which implies the prognostic value of CCR5 in melanoma patients and provides a novel insight into CCR5-targeted melanoma treatment strategies.